Pain relief Dolo 650 Tablet is a common painkiller for treating aches and pains. It is widely used and rarely causes any side effects if taken properly. To get the most benefits, take it as prescribed. Do not take more or for longer than needed as that can be dangerous. Treatment of Fever Dolo 650 Tablet is also used to reduce a high temperature (fever). It works by blocking the release of certain chemical messengers that cause fever. It may be prescribed alone or in combination with other medicines. Take it as prescribed by the doctor.